Your Source for All Things Chlorophyll:

Top 15 Benefits of Chlorophyll

(according to published reports)

1.      Enhance Overall Well-Being

2.      Oxygenates Our Body

3.      Helps Boost Energy Levels

4.      Blood-Building Properties

5.      Super Potent Antioxidant & Nutrient Rich

6.      Increases Cellular Energy Production

7.      Protects Your Liver Naturally & Improves Liver Detoxification

8.      Promotes Cleansing & Detox

9.      Boosts Your Immune System

10.    Anti-Inflammatory & Fights Oxidative Stress

11.    Ward Off Chronic Diseases

12.    Beautiful Skin & Skin Healing

13.    Anti-Aging

14.    Weight Loss

15.    Helps Fight Cancer

01. Enhance Overall Well-Being

“The potential benefits of chlorophyll include improving health, boosting energy, and fighting illnesses.” – Source: Medical News Today

“Research Shows the Health Benefits of Eating a Chlorophyll-Rich Diet. Chlorophyll is a great source of vitamin A, C, E, and K –  as well as being high in many antioxidants and minerals like magnesium, iron, calcium, and potassium. In addition to being packed with goodness, chlorophyll increases the flow of oxygen throughout the body, can cleanse toxins and prevent your body from absorbing harmful pollutants, improves respiratory functions, and soothes inflammation – as well as aids in healing.” – Source: Be Well by AK

“Chlorophyll is soluble in fat particles, which are absorbed directly into blood via the lymphatic system. In other words, when the ―blood‖ of plants is absorbed in humans it is transformed into human blood, which transports nutrients to every cell of the body. Chlorophyll present in wheatgrass can protect us from carcinogens; it strengthens the cells, detoxifies the liver and blood stream, and chemically neutralizes the polluting elements.” – Source: Functional Foods in Health and Disease

"Chlorophyll refers to the phytochemical that gives plants their green color and pigmentation. This chemical is responsible for absorbing solar energy to facilitate photosynthesis, a process in which plants convert energy from sunlight into sugars. You can get chlorophyll from green vegetables or through liquid supplementation purchased from vitamin stores. Chlorophyll provides nutritional benefits to the body and helps keep you healthy.” – Source: Livestrong

“The harnessing of solar energy by photosynthesis depends on a safety valve that effectively eliminates hazardous excess energy and prevents oxidative damage to the plant cells. Many of the compounds that protect plant cells also protect human cells. Improving plant resistance to stress may thus have the beneficial side effect of also improving the nutritional quality of plants in the human diet. “ – Source: Science Mag

“Chlorophyll, the green plant pigment, a 'real life force' of living beings, besides synthesizing food, is a great source of vitamins, minerals and other phytochemicals. Adding chlorophyll rich food to our diet fortifies our body against health disorders.” – Source; National Institute of Oceanography

“Sodium copper chlorophyllin (CHL) is a semi-synthetic mixture of water-soluble sodium copper salts derived from chlorophyll, widely used as food dye (Chernomorsky, Rancourt, Virdi, Segelman, & Poretz, 1997;Tumolo & Lanfer-Marquez, 2012). Its anti-mutagenic and anti-carcinogenic activities against numerous dietary and environmental agents, including the mycotoxin aflatoxin B 1 , heterocyclic amines, and polycyclic aromatic hydrocarbons have been recorded (reviewed in Tumolo & LanferMarquez, 2012).” – Source: Food Research International Journal

“Recent research now shows that chlorophyll has medicinal properties. Estimating the chlorophyll content in these plants could portray how chlorophyll plays an important part in their medicinal properties. Here are some of the known chlorophyll benefits [6]: It has been seen to help in the growth and repair of tissues. Chlorophyll helps in neutralizing the pollution that we breathe in and intake every day - a good supplement for smokers.” – Source: Journal of Pharmacy Research

“The harnessing of solar energy by photosynthesis depends on a safety valve that effectively eliminates hazardous excess energy and prevents oxidative damage to the plant cells. Many of the compounds that protect plant cells also protect human cells. Improving plant resistance to stress may thus have the beneficial side effect of also improving the nutritional quality of plants in the human diet. The pathways that synthesize these compounds are becoming amenable to genetic manipulation, which may yield benefits as widespread as improved plant stress tolerance and improved human physical and mental health.” – Source: Science Journal

 “Chlorophyll extracted from the wheatgrass plant or its synthetic derivative chlorophyllin has also been implicated in this clinical condition. The antioxidant mechanism of the various wheatgrass constituents may be responsible for the beneficial effects. The enhanced anti-oxidative capacity of the RBCs may prolong the survival time of not only the newly formed cells, but also of the transfused RBCs [28]… The patients reported general well-being, improved appetite and reduced musculo-skeletal aches and pains [17].” – Source: International Journal of Chemical Studies

“Thylakoids and chloroplasts harbor several vital metabolic processes, but are most importantly associated with photosynthesis. The undisturbed functioning of this process necessitates the ceaseless synthesis of photosynthetic pigments, including closed tetrapyrroles such as chlorophylls (Chls). Chls probably represent the most abundant natural pigment molecules which are via photosynthesis not only crucial for the autotrophic production of food sources for heterotrophic organisms but have also contributed to oxygen production essential for aerobic metabolism. This review first briefly discusses the physico-chemical properties, biosynthesis, occurrence, in vivo localization and roles of the different Chl pigments. Then we provide a detailed overview of their potential applications in the food industry and medicine.” – Source: Mini Reviews in Medicinal Chemistry

“Sodium coppy chlorophyllin, on the other hand, has been studied separately as an individual synthetic compound, with respect to its antimutagenic and cancer-preventative properties, as already reported in original and review articles [2-7]. Both chlorophylls and chlorophyllins are able to reduce mutagenic activity of a number of dietary and environmental carcinogens, but in general, copper-complexed chlorophyllins seem to be effective.  A comparative study showed chlorophyliin to be more effective antimutagen than retinol.” – Source: Handbook of Natural Colorants

“This means that when ingested, liquid chlorophyll can actually help to do the job of hemoglobin (hemoglobin is so vital to the health of our blood – in fact, blood is approx 75% hemoglobin). It helps to rebuild and replenish our red blood cells, boosting our energy and increasing our wellbeing almost instantly.

I know this sounds a bit like the old ancient Japanese legend that eating brains makes you smarter – BUT – eating/drinking liquid chlorophyll can increase the quality AND quantity of your red blood cells.” – Source: Live Energized

“The chlorophyll molecule is also remarkably similar to human plasma, except that it carries magnesium in its center instead of iron.  Green foods help human bodies build red blood cells. In essence, eating any of the chlorophyll-rich foods is almost like giving yourself a little transfusion to help treat illness, enhance immunity and sustain well-being.” Source: Detoxication

“Chlorophyllin is a water-soluble derivative of the green plant substance chlorophyll. In multiple studies, chlorophyllin exhibits powerful anticarcinogenic effects in regards to a variety of environmental toxins.6-8 The way chlorophyllin accomplishes this is by targeting a number of molecules and pathways involved in cancer development, such as protecting against mutations of the p53 tumor suppressor gene. Cell proliferation is partially controlled by the p53 gene, so protecting healthy expression of p53 is a critical factor that helps guard against cancerous changes.18 - Source: Life Extension Magazine

“Emil Burgi of Berne, Switzerland, made further researches on chlorophyll which were destined to establish sound therapeutic values of chlorophyll. He says, in part, "Chlorophyll is recommended as an excellent specific for influencing anemia of various kinds, for bettering the general condition of health, for improving the action of the heart and for reducing blood pressure in cases where it is abnormally high. In cases of heart block, weakness of the heart, etc., in conjunction with abnormal blood pressure (usually due to arteriosclerosis) the administration of chlorophyll brought about a slow but rather considerable improved action of the heart. It stimulated peristalsis, improved the intestines and was a mild diuretic.” – Source: Foundation for Advancement in Cancer Therapy

OTHER RESOURCES

02. Oxygenates Our Body

“Chlorophyll strengthens the blood-producing organs, prevents anemia and gives the body an abundance of oxygen. Loaded with antioxidant power, chlorophyll exerts beneficial effects against cancer, insomnia, dental ailments, sinusitis, pancreatitis and kidney stones. Chlorophyll has anti-aging and anti-microbial properties and helps strengthen the immune system. “ – Source: Jane’s Healthy Kitchen

“There is a reason why we are told to ‘eat our greens’ because as a general rule, the greener the plant, the richer it is in the oxygen-carrier chlorophyll. As mentioned above, chlorophyll oxygenates our bodies. Its assimilation through the ingestion of plants and vegetables enables oxygen to be taken up efficiently by the red blood cells. Without sufficient oxygen, our bodies become sluggish because all the processes rely on the cells being sufficiently oxygenated. With insufficient oxygen, energy production is greatly diminished and our metabolism drops. In 1931, the Nobel Prize Winner for physiology and medicine, Dr Otto Warburg established that oxygen deprivation was a major cause of cell mutation. Increasing our intake of chlorophyll rich foods or taking chlorophyll by way of supplementation definitely increases oxygen uptake by the cells of our bodies.” – Source: Victoria Health

“Green vegetables contain chlorophyll, which is close in atomic structure to human blood. When you eat green vegetables, the chlorophyll allows blood to transport oxygen to cells. Foods rich in chlorophyll include spinach, broccoli, kale, mustard greens, spirulina, chlorella and blue-green algae.” – Source: Rejuvena Health & Aesethics

“Chlorophyll oxygenates the entire body-feeding the cells to create hemoglobin.” – Source: A Pathway to Healing

“Although the intake of chlorophyll before the test could not enhance athlete’s performance, it could provide a more effective transportation of oxygen in the blood.  Before the test, the intake of chlorophyll actually increased the exclusion rate of lactate, which helps athletes recover more quickly.” – Source: Institute of Coaching Science

“Allergies to some nuts aside, a diet highest in oxygen is a raw food diet with a high concentration of fruits, green vegetables and sprouted seeds and nuts. This is largely because live fruits, green vegetables and sprouted/soaked seeds and nuts are composed of water, which is hydrogen and oxygen and mostly oxygen by weight. The green in the vegetable is chlorophyll which is very close in atomic structure to human blood.” Source: Breathing

 “Plus, it could help you go faster for longer. “While I haven’t seen direct studies linking chlorophyll consumption to athletic performance, increasing blood production helps better oxygenate cells, which is helpful for endurance sports,” says Jacobson.” -Source: Spartan

 “One of chlorophyll’s more important functions in the Hippocrates Diet is oxygenation of the bloodstream. On. High-fat and high protein diet our oxygen supply is reduced. Dr. John Gainer, reporting in Science News, August, 1971, stated that even a moderate increase in blood plasma protein can reduce oxygen levels of the blood by as much as 60 percent.  I have found that without sufficient oxygen in our blood we develop symptoms of low energy, sluggish digestion, and metabolism.” – Source: Hippocrates

“Chlorophyll is one of the few substances that brings more oxygen into the cells, while at the same time strengthening cell walls from oxidative (free radical) damage. In the 1940s and 1950s (before antibiotics and medications became standard protocol), chlorophyll was used in thousands of surgeries to help heal tissues and to stop bacterial infections. Dr. Gruskin (the Director of Experimental Pathology at Temple University during that time) wrote in The American Journal of Surgery, after having treated over 1200 patients with chlorophyll that “it is interesting to note that there is not one single case recorded in which improvements or cure has not taken place.” – Source: National Therapy Institute

Other Resources

03. Helps Boost Energy Levels

“Chlorophyll water suppresses appetite, aids in weight loss, decreases spikes in insulin which lessens cravings, helps with skin healing, helps in detoxifying the blood, reduces the risk for cancer, increases energy, helps in eliminating odors (as a natural deodorant), and helps in boosting the immune system,” says Kantor.” – Source: Spartan

“Chlorophyll is the life-force of plants. As you ingest it, you’ll take on its vibrational energy. While it’s not as good as a lazy sleep-in, it will help carry you through the day with more clarity and zest.” – Source: Food Coach NYC

 “Chlorophyll is the green molecule in plant cells that absorbs sunlight during photosynthesis. Interestingly, it not only provides plants with energy; chlorophyll benefits human energy production as well.” – Source: University Health News

 “Sunlight is the most abundant energy source on this planet. However, the ability to convert sunlight into biological energy in the form of adenosine-5'-triphosphate (ATP) is thought to be limited to chlorophyll-containing chloroplasts in photosynthetic organisms. Here we show that mammalian mitochondria can also capture light and synthesize ATP when mixed with a light-capturing metabolite of chlorophyll. The same metabolite fed to the worm Caenorhabditis elegans leads to increase in ATP synthesis upon light exposure, along with an increase in life span. We further demonstrate the same potential to convert light into energy exists in mammals, as chlorophyll metabolites accumulate in mice, rats and swine when fed a chlorophyll-rich diet. Results suggest chlorophyll type molecules modulate mitochondrial ATP by catalyzing the reduction of coenzyme Q, a slow step in mitochondrial ATP synthesis. We propose that through consumption of plant chlorophyll pigments, animals, too, are able to derive energy directly from sunlight.” – Source: Journal of Cell Science

 “Plants and people have a lot more in common than we might have realized. The hundreds of enzymes that organize physiology inside a plant’s body turn glucose into all kinds of vitamins, antioxidants, and other chemical compounds, and various biochemical reactions inside our body use glucose as fundamental source of energy. Chlorophyll is often described as the ‘blood of plants’ and chlorophyll-rich foods have been linked with increasing hemoglobin content. Tributes to the late Prof. Willstatter for elucidating chlorophyll’s chemical structure, and conclusively showing its close resemblance to human blood.” – Source: International Society of Agricultural Meteorology  

 “Chlorophyll is pure energy converted into liquid and one of the most effective properties of this chemical compound is it’s ability to enhance the production of red blood cells in humans, a feature critical for those who are living an active life.” – Source; Superfoods Explained

 "In addition to being nutritionally fabulous for you, chlorophyll is a detoxifier that promotes energy and weight loss," says holistic nutritionist Elissa Goodman. Chlorophyll promises a ton of great benefits that are guaranteed to win you over.” – Source: Spoon University

 “A recent research report asks the question of whether mammals can also generate energy from from sunlight. Are we human plants? In the study the "powerhouse" of the cell, the mitochondria, were shown to generate ATP energy when exposed to sunlight when fed a chlorophyll rich diet. This finding, if confirmed, might explain why people feel energized by being in the sunshine, particularly if their diet is high in chlorophyll rich foods.” – Source: Huffington Post

 “Chlorophyll has many health benefits, and largely because of its similarity to hemoglobin. When humans take in chlorophyll, this substance does the job of hemoglobin, and this is related to the replenishing of red blood cells. Instant effects reported are improved circulation, a boost of energy, better moods and a cleansing of the body.” – Source: Exercise

 “Chlorophyll, which gives green plants their color, helps the blood carry more oxygen, which boosts energy levels and general well-being. Chlorophyll also enhances the body’s ability to eliminate toxins, helping increase energy production. Green foods powders are a concentrated source of chlorophyll and include chlorella, spirulina, kelp, and moringa.” – Source: Wellness Magazine

 “Chlorophyll is pure energy converted into liquid and one of the most effective properties of this chemical compound is to its ability to enhance the production of red blood cells in humans, a feature critical for those who are living an active life.  The higher number of red blood cells, the better oxygenation.” – Source: Superfoods Explained: A Fact Based Analysis of Foods with Uncommonly High Nutritive Value

 “Sunlight is the most abundant energy source on this planet. However, the ability to convert sunlight into biological energy in the form of adenosine-5'-triphosphate (ATP) is thought to be limited to chlorophyll-containing chloroplasts in photosynthetic organisms. Here we show that mammalian mitochondria can also capture light and synthesize ATP when mixed with a light-capturing metabolite of chlorophyll. The same metabolite fed to the worm Caenorhabditis elegans leads to increase in ATP synthesis upon light exposure, along with an increase in life span. We further demonstrate the same potential to convert light into energy exists in mammals, as chlorophyll metabolites accumulate in mice, rats and swine when fed a chlorophyll-rich diet.” – Journal of Science

 “The study titled, "Light-harvesting chlorophyll pigments enable mammalian mitochondria to capture photonic energy and produce ATP", indicates that by eating a chlorophyll-rich diet mammals (and by implication humans) can capture specific wavelengths of sunlight radiation that will translate into increased energy within the powerhouses of the cell known as the mitochondria.” – Source: Green Med Info

OTHER RESOURCES

1. 4 Incredible Chlorophyll Benefits

2. Effects of Protracted Chlorophyll Intake In Endurance Athletes

3. Relationship of Chlorophyll Supplement and Platelet-Related Measures in Endurance

4. The Effect of Chlorophyll Intake Before Exercise on Blood Lactate and the Pressure of Oxygen

5. Chlorophyll: Structural Properties, Health Benefits and It's Occurrence in Virgin Olive Oils

6. Chlorophyll-Mediated Energy Capture in Animal Mitochondria

7. Light-Harvesting Chlorophyll Pigments Enable Mammalian Mitochondria to Capture Photonic Energy and Produce ATP

8. The Benefits of Chlorophyll

9. Superfood Spotlight: Chlorophyll

10. Why You Should Try Chlorophyll Water

11. The Hippocrates Diet and Health Program

12. Assessment of Degradation and Instestinal Cell Uptake of Carotenoids and Chlorophyll Derivatives from

13. Spinach Puree Using An In Vitro Digestion and Caco-2 Cell Model

14. Effects of Protracted Chlorophyll Intake In Endurance Athletes

15. Osteopathy and Micro-Nutrition for the Performance of Professional Athletes

04. Blood Building Properties

Chlorophyll is chemically similar to hemoglobin, a protein that is essential in red blood cells as it carries oxygen around a person's body. Researchers have suggested that wheatgrass juice, which is rich in chlorophyll, may be helpful in treating hemoglobin deficiency disorders, such as anemia and thalassemia.”  Source: Medical News Today

“Some people suggest that liquid chlorophyll can build your blood by improving the quality of red blood cells. A 2004 pilot study found that wheatgrass, which contains about 70 percent chlorophyll, reduced the number of blood transfusions needed in people with thalassemia, a blood disorder.” – Source: Healthline

“Chlorophyll aids in restoring and replenishing red blood cells. It works at molecular and cellular levels and has the ability to regenerate our body. [4] It is rich in live enzymes that help in cleansing blood and enhances its ability to carry more oxygen. [5] It is a blood builder and is also effective against anemia which is caused by a deficit of red blood cells in the body.” – Source: Organic Facts

“Thus, it should be made part of daily dietary intake in order to explore its utmost benefits. The structural homology of chlorophyll with hemoglobin indicates the role of chlorophyll as a blood builder in various clinical conditions involving hemoglobin deficiency - thus the name "green blood".- Source: International Journal of Chemical Studies   

 “Chlorophyll is a substance found in plants, basic for photosynthesis. Recent studies show anti-cancer and antioxidant effects; the purpose of this study is to verify the effects of protracted chlorophyll intake on blood counts parameters and iron levels in volunteers practicing endurance sports, to investigate hypothesized anti anemic properties.” – Source: Sport Science Health  

“Hemin and chlorophyllin are known to inhibit strongly the mutagenicity of benzo[a]pyrene in the Salmonella assay. To further investigate this phenomenon, a series of these pyrrole pigments including pure samples of Cu- and Fe-chlorins were tested for their potency to inhibit the mutagenicity of benzo[a]pyrene and its metabolites, benzo[a]pyrene-7,8-diol, benzo[a]pyrene4,5-epoxide, and benzo[a]pyrene-7,8-diol-9,10-epoxide.” – Mutation Research Journal 

 “According to the Encyclopedia of Natural Medicine, liquid chlorophyll has the power to increase the amount of red blood cells in the body. Your red blood cells contain hemoglobin, which is a molecule responsible for transporting oxygen to the rest of your body. In addition to improving oxygen transportation, chlorophyll is a powerful antioxidant.” – Source: The Daily Meal  

 “Chlorophyll is generally known for its ability to help increase the production of red blood cells. That's because its chemical structure closely resembles hemoglobin, an essential protein located in the bloodstream. A high red blood cell count can help transfer oxygen to your cells more efficiently.” – Source: Dr. Mercola

 “Chlorophyll not only cleanses the blood of impurities, but also builds up the blood with important nutrients, promotes regularity, and inhibits cellular damage from radiation.” – Source; Prescription for Nutritional Healing

 “Chlorophyll has a cleansing effect on the blood and contributes blood-building nutrients, according to nutritionist Phyllis Balch, author of the book "Prescription for Nutritional Healing." Chlorophyll also protects your cells against the damaging effects of radiation, such as from X-rays or MRIs. It is abundant in leafy green vegetables, wheatgrass, barley grass and alfalfa grass.” – Source: Healthfully

 “Chlorophyll not only cleases the blood of impurities, but also builds up the blood with important nutrients, promotes regularity and inhibits cellular damage from radiation.” – Source: Prescription for Nutritional Healing: Fourth Edition by Phyllis A. Balch CNC

“Chlorophyll consumption increases the number of red blood cells and, therefore, increases oxygen utilization by the body. Chlorophyll also reduces the binding of carcinogens to DNA in the liver and other organs. It can also break down calcium oxalate kidney stones for elimination. Another function of chlorophyll may be to inactivate the actions of molds. The absorption of a mold toxin called aflatoxin B, linked to liver cancer, is reduced by chlorophyllin.” – Source: Huffington Post

05. Super Potent Antioxidant Action & Nutrient Rich

 “Chlorophyll's status as a superfood is due to its nutritional and potent antioxidant properties. It protects cells from oxidative damage by eliminating free radicals. [7] One plant known for its high chlorophyll levels, Conyza triloba, showed very active superoxide scavenging behavior. An in vitro study found it capable of reducing free radicals while reducing cell damage. [8] Source: Global Healing Center

“Cu-chlorophyllin, tested by both methods, presented a higher antioxidant activity than that of natural chlorophylls, showing the importance of the nature of the chelated metal in the porphyrin ring. The mechanism of antioxidant activity displayed by the natural chlorophyll derivatives does not seem to be based on the ability to donate hydrogen but maybe, on the protection of linoleic acid against oxidation and/or preventing decomposition of hydroperoxides.” – Source: Food Research International

“Several studies reported copper chlorophyllin had antioxidant activity against oxidative stress in human and animals in vivo and in vitro.” – Source: Toxicology Letters

“The mechanism of the antimutagenicity of chlorophyllin in these experiments is not known; however, chlorophyllin is an antioxidant. Scavenging of radicals and/or interaction with the active group of mutagenic compounds may be responsible for its antimutagenic activity. The data reported here indicate that chlorophyllin is potentially useful as an antimutagenic agent.” – Source: Mutation Research Letters

“Next, we examined the antioxidant activity of chlorophylls. Using an in vitro assay, all chlorophylls tested showed the capacity to scavenge peroxyl radicals in a dose-dependent manner with chlorophyllin being the most potent (Figure 3).” – Source: Oxidative Medicine and Cellular Longevity Journal

“The antioxidant effects of chlorophyllin (CHL), a water-soluble analog of the green plant pigment chlorophyll, on different reactive oxygen species (ROS) were investigated by electron spin resonance (ESR) spectroscopy. As a standard, we have used the ability of CHL to scavenge the stable 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical. CHL inhibits the formation of 5,5-dimethyl-1-pyrroline-N-oxide adduct with hydroxyl radical (DMPO-OH adduct) generated by γ-radiation in a dose-dependent manner. At a concentration of 1 mM, CHL caused more than 90% inhibition of ESR signal intensity of this adduct. However, the results obtained with the Fenton reaction were different. We also found evidence for the inhibition of 1O2-dependent formation of the 2,2,6,6-tetramethyl-piperidine oxide (TEMPO) radical during photosensitization of methylene blue with visible light. CHL was also able to inhibit hydrogen peroxide induced oxidation of phenol red. The rate constant of the reaction of CHL with H2O2 was found to be 2.7×106 M-1s-1. In conclusion, CHL has potent antioxidant ability involving scavenging of various physiologically important ROS.” – Source: Radical Research Journal

“Chlorophyll from S. androgynus and Cu-chlorophyllin possess antioxidant potentials to protect against toxicities induced by sodium nitrate.” – Source: Journal of Toxicology 

“The results revealed that the Zn-pheophytins showed the highest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and β-carotene bleaching activities, followed by chlorophylls and pheophytins. Additionally, Zn-pheophytins showed substantial inhibitory activity against lipopolysaccharide (LPS)-induced NO production in RAW 264.7 cells. Furthermore, Zn-pheophytins remarkably suppressed LPS-induced expression of inducible nitric oxide synthase (iNOS) in RAW 264.7 cells and showed no cytotoxicity. Our findings indicated that Zn-pheophytins have strong antioxidant and anti-inflammatory properties and can therefore be a potential source of bioactive compounds for nutraceutical, cosmetic, and pharmaceutical applications.” – Source: Food Chemistry Journal

“A study published in the Journal of Food Science states that chlorophyll possesses strong antioxidant capacity along with a significant amount of essential vitamins. [12] These effective radical scavengers in it help neutralize harmful molecules and guard against the development of various diseases and damages caused as a consequence of oxidative stress for which free radicals are responsible. [13]” Source: Organic Fact

 “Chlorophyll also recharges depleted antioxidants. Generally, an antioxidant can only execute its function once. After an antioxidant has neutralized a free radical, it can no longer interact with other free radicals. Chlorophyll, however, can donate electrons to depleted antioxidants. This reactivates them, allowing them to continue scavenging free-radical species.[4] For example, chlorophyll regenerates ubiquinol, which can then go on to regenerate even more antioxidants, such as vitamins E and C.[5] Eating vegetables can increase free radical protection tremendously, not only by delivering new antioxidants to the body, but also by regenerating ones that already exist.” – Source: University Health News

“There’s a reason that chlorophyll is absolutely essential to the survival and growth of plants. Besides being involved in the process of photosynthesis, it’s also jam-packed with tons of nutrients that can be beneficial to humans as well. Rich in vitamins A, C, K, and E, chlorophyll supports everything from blood clotting to healthy skin and vision. It’s also full of essential fatty acids and important minerals like magnesium, iron, calcium, and potassium.” – Source: Yuriel Kaim

“Sodium copper chlorophyllin (SCC), a mixture of water-soluble chlorophyll derivatives, is used as both a food colorant and a common dietary supplement. Although the potential antimutagenic and antioxidant properties of this commercial preparation have been demonstrated, limited information is available on its digestion and absorption by humans.” – Source: Journal of Agriculture Food Chemistry

“This study investigated whether chlorophyllin (CHL) could induce antioxidant enzymes and confer protection against oxidative damage. The results showed that CHL could induce HO-1 and NQO1 expression in human umbilical vein endothelial cell (HUVEC) in a time- and dose-dependent manner and protect them against hydrogen peroxide caused oxidative damage. The induction of HO-1 and NQO1 by CHL was accompanied with the accumulation of transcription factor Nrf2 in nucleus and the activation of PI3K/Akt signalling pathway. Additionally, the specific inhibitor of PI3K/Akt could obviously decrease not only the induced expression of HO-1 and NQO1 but also the antioxidant effect of CHL. In conclusion, this study proved that CHL exerts antioxidant effect by inducing HO-1 and NQO1 expression mediated by PI3K/Akt and Nrf2. One thinks CHL may have promise to be prophylactic pharmaceuticals without adverse effects.” – Source: Free Radical Research Journal

“Other research has suggested that chlorophyll may have antioxidant properties.” – Source: Health

“Well, for one thing, it’s a potent antioxidant with some seriously powerful detoxifying properties—and who wouldn’t be down with that? “Chlorophyll binds to harmful procarcinogen chemicals—toxins that turn into [cancer-promoting] carcinogens when metabolized—and inhibits them from being absorbed into the intestines,” says Carly Brawner, holistic nutritionist and health coach at Frolic and Flow.” – Source: Well+Good

OTHER RESOURCES

1. Antioxidant and Antimutagenic Activity of Dietary Chlorophyll

2. Chlorophyll and Chlorophyllin

3. Study of Chlorophyll-Related Compounds from Dietary Spinach in Human Blood

4. Protection of Chlorophyllin Against Oxidative Damage by Reducing HO-1 and NQO1

5. Chlorophyllin as a Protector of Mitochondrial Membranes Against Gamma-Radiation and Photosensitization

6. The Antioxidant and Free Radical Scavenging Activities of Chloroophylls and Pheophytins

7. Investigation of Antioxidant Capacity and Phytochemical Composition of Sun Chlorella

8. Chlorophyll and Total Phenolic Contents, Antioxidant Activities and Consumer Acceptance Test of Processed Grass Drinks

9. Antioxidant Properties of Chlorophyll-Enrich and Chlorophyll Depleted Polyphenolic Fractions

10. Study of Antioxidant Activity of Chlorophyll From Some Medicinal Plants

11. Chlorophyll Content and Antioxidant Activity of Sunflower Oil With Aromatic Raw Materials

12. Scavenging of Reactive Oxygen Species by Chlorophyllin

13. Sodium Copper Chlorophyllin Immobilization onto Hippospongia Communis Marine

14. Demosponge Skeleton and It’s Antibacterial Activity

15. Investigation of Genotoxic and Antigenotoxic Activities of Chlorophylls and Chlorophyllin in Cultured V79Cells

16. Oxidative Stress, Disease and Cancer

17. An Evidence Based Approach to Phytochemicals and Other Dietary Factors

18. Antioxidant Effects of Chlorophyll and Pheophytin on the Autoxidation of Oils in the Dark. The Mechanism of Antioxidation Action of Chlorophyll.

19. Synthesis, Characterization, and Functional Properties of Chlorophylls, Pheophytins, and Zn-Pheophytins

20. Antioxidant Capabilities and Polyphenolics of Chinese Cabbage Leaves
    

06. Increases Cellular Energy Production

“In humans, the energy molecule ATP is manufactured by mitochondria, which are small organelles that exist in many different types of cells. Chlorophyll accumulates inside the mitochondria of mammals that eat a chlorophyll-rich diet.[2] Once there, the chlorophyll can transfer electrons to coenzyme Q-10, an extremely important molecule that is discussed here. This greatly accelerates ATP production in the mitochondria, and more energy is available as a result.[3]  Source: University Health News

“According to Dr. Joshua Zeichner, Director of Cosmetic & Clinical Research in Dermatology at New York's Mount Sinai Hospital, there's been some data to suggest that liquid chlorophyll promotes red blood cell production, which means it also may help promote oxygen delivery to your tissues, which probably accounts for why I noticed an almost instantaneous change in my face's tone. The dullness started to recede within days, I looked more awake, and the dry patches along my cheeks started to clear up.” – Source: Glamour

 “The most amazing property of chlorophyll might be the fact that its molecular structure is almost identical to that of hemoglobin, the substance our bodies use to build and transport red blood cells. Therefore, chlorophyll can actually help do the job of hemoglobin, increasing the quantity and quality of red blood cells in your body. Amazing fact: it’s even been known to be used in hospital IVs for pain and swelling! It is only natural that “green sunshine” should bring you energy: taking chlorophyll in capsule, powder, or liquid form will bring you an instant boost of energy and vitality. More healthy red blood cells mean better oxygen absorption in the bloodstream, which means more all around energy and oxygen utilization in the body. And because of its blood health-improving qualities, it can cleanse and rejuvenate your body at a cellular level.” – Source: The Chalkboard Mag

“It is also found to be useful in assimilating and chelating calcium and other heavy minerals. It had been seen to have a good potential in stimulating red blood cells to improve oxygen supply. Along with other vitamins such as A, C and E, chlorophyll has been seen to help neutralize free radicals that do damage to healthy cells.” – Source: Journal of Pharmacy Research

Chlorophyll seems to slow the rate that harmful bacteria can reproduce, which speeds up wound healing and infection prevention. It has been found that it lowers inflammation caused by injuries or wounds, promotes healthy healing and even control odors caused by bacteria.

07. Protect Your Liver Naturally & Improves Liver Detoxification

 “In addition to its neuroprotective and appetite-suppressing effects, chlorophyll promotes liver health and balances the gut flora. A recent study posted in Frontiers in Physiology in 2018 has found that chlorophyllin may help relieve hepatic fibrosis symptoms by reducing harmful gut bacteria. As mentioned earlier, this plant compound is derived from chlorophyll and has similar properties. The study also indicates that chlorophyllin may reduce liver inflammation and protect the small intestine in mice with hepatic fibrosis. Its beneficial effects on the gut microbiota hold promise for future research.” - Source: Livestrong

“Chlorophyll also has the ability to act as a liver protecting agent. Chlorophyll and its derivative chlorophyllin inhibit the metabolism of these procarcinogens which may impair the DNA and also lead to liver cancer and hepatitis. Studies have also shown that chlorophyll cal also acts as a phytochemical compound in the reduction of tumorigenesis.[2]” – Source: Asian Journal of Pharmaceutical Technology & Innovation

“Another way by which chlorophyll might protect healthy cells and bodily tissue is by increasing phase II biotransformation enzymes. These promote optimal liver health and therefore the body’s natural elimination of potentially harmful toxins. Some early studies involving animals show that chlorophyllin may reduce the risk for aflatoxin-induced liver damage or liver cancer by increasing activity of these phase II enzymes and removing bodily toxins.  In China, a randomized, placebo-controlled intervention trial involving 180 adults with a high risk of hepatocellular carcinoma and chronic hepatitis Binfection gave participants either 100 milligrams of chlorophyllin or a placebo before meals three times daily. After 16 weeks of taking chlorophyllin, AFB1 levels dropped an average of 55 percent more in those taking chlorophyllin compared tothose taking the placebo, suggesting chlorophyll benefits liver health in a useful and safe way.” - Source: Dr. Axe

“It has purifying qualities which help in detoxification of the body. In the book “Chlorella: The Emerald Food“, it is clearly mentioned that there is an abundance of oxygen and a healthy flow of blood in the body because of chlorophyll. [4] This helps you get rid of harmful impurities and toxins. It forms complexes with the mutagens and has the ability to bind and flush out the toxic chemicals and heavy metals such as mercury from the body. This helps in detoxifying and reviving the liver. It is also effective in reducing the harmful effects of radiations and helps eliminate pesticides and drug deposits from the body.” – Source: Organic Facts

 “Fortunately, studies show that chlorophyllin has the potential to significantly reduce the risk of liver cancer induced by aflatoxin by binding to carcinogenic byproducts of aflatoxin metabolism and therefore, decreasing bioavailability of these cancer-causing chemicals.32-33In a study in the journal Cancer Prevention Research, researchers showed that in volunteers, ingestion of 150 mg of chlorophyllin significantly decreased the absorption of aflatoxin B.32An even more compelling study on the preventive power of chlorophyllin was done in Qidong, China, a province where the population is known to have a high exposure to aflatoxins and therefore, putting them at high risk of liver cancer.33 In this randomized, double-blind, placebo-controlled study, 180 men and women were randomized to receive either 100 mg of chlorophyllin or a placebo three times daily over a four-month period.” – Source: Life Extension Magazine

“Many of us (me included) reach for that glass of wine or cocktail to unwind at the end of the day. For women in particular, just one drink can raise estrogen levels by 10% or more. When you have excess estrogen, your liver has to work overtime, and it also causes brain inflammation. This can lead to a heightened response to normal everyday stressors. Chlorophyll is a potent liver detoxifier and can help combat the negative effects of alcohol.” – Source: Bon Appetit  

OTHER RESOURCES

1. Medicinal Uses of Chlorophyll: A Critical Overview

2. Modulation of Metabolic Detoxification Pathways Using Food and Food-Derived Components

3. Chlorella: The Ultimate Green Food

4. Chlorophyll as Therapy by H.E. Kirschner, M.D.

5. 7 Research-Based Treatments & Benefits of Chlorophyll

6. Health Benefits of Chlorophyll

7. Chlorophyll Benefits: The Plant Pigment that Heals + Detoxes Better Than All

8. ChlorophyllL The Great Detoxer

9. 6 Ways to Detox With Chlorophyll by Just Cleansing

10. Body Detox: A Guide to Health and Rejuvenation

11. Prescription for Nutritional Healing

12. E2F4 and Ribonucleotide Reductase Mediate S-phase Arrest in Colon Cancer Cells

13. Treated with Chlorophyllin

14. 5 Easy Ways to Feel Less Stressed Right Now by Dr. Tiffany Lester

15. Nutrition and Cancer: A Review of the Evidence for An Anti-Cancer Diet

16. Beneficial Effect of Wheatgrass Juice on Some Biochemical Parameters in Type 2 Diabetic Subjects With Reduced Lymphocytes Count

17. The Detox Revolution

18. Chlorophyll and Chlorophyllin as Modifers of Genotoxic Effects

19. Identification and Characterization of Chloro e(4) ethyl ester in Sera Individuals Participating in the Chlorophyllin Chemoprevention Trial

20. Chlorophyll-Enhanced Excretion of Urinary and Fecal Mutagens

21. Effect of Dietary Chlorophyll Derivatives on Mutagenesis and Tumor Cell Growth
    
    

08. Promotes Cleansing and Detox

“Environmental pollutants such as toxic metals can quickly destroy health. Chlorophyll binds with toxic metals to hamper absorption, and research has shown it can do the same with some carcinogens. A crossover study with 4 human volunteers tested chlorophyll’s ability to remove ingested aflatoxin, a known carcinogen. Each volunteer received three servings of the aflatoxin, followed with a meal, the latter two included a tablet of chlorophyll. The results showed rapid elimination with 95% evacuated within 24 hours. [5] Source: Global Healing Center

“Chlorophyllins are derivatives of chlorophyll in which the central magnesium atom is replaced by other metals, such as cobalt, copper or iron. An attempt has been made in this article to review the relative efficacy of chlorophyll and chlorophyllin in modifying the genotoxic effects of various known toxicants.” – Source: Genetic Toxicology Journal

“Chlorophyll is a primary aid for organ detoxification, particularly the liver. It helps to neautralize and remove drug deposits from the body, purify the blood and counteracts acids and toxins in the system.” – Source: Healthy Healings Detoxification

“Modification of the metabolism and detoxification of carcinogens: To initiate the development of cancer, some chemicals (procarcinogens) must first be metabolized to active carcinogens that are capable of damaging DNA or other critical molecules in susceptible tissues. Since enzymes in the cytochrome P450 family are required for the activation of some procarcinogens, inhibition of cytochrome P450 enzymes may decrease the risk of some types of chemically induced cancers. In vitro studies indicate that chlorophyllin may decrease the activity of cytochrome P450 enzymes (5, 13). Phase II biotransformation enzymes promote the elimination of potentially harmful toxins and carcinogens from the body. Limited data from animal studies indicate that chlorophyllin may increase the activity of the phase II enzyme, quinone reductase (14).” – Source: Oregon State University

“Chlorophyll builds strong hemoglobin and swiftly purifies the bloodstream, thereby supporting the entire detox process be enhancing the blood’s capacity to hold oxygen and deliver it to the tissues. As Dr. Bernard Jensen, one of the leading authorities on detox therapy states, “Chlorophyll can speed up the rate of cleansing the bowel, bloodstream and live.” – Source: The Tao of Detox

More resources

1. Chlorophyll Benefits: The Plant Pigment that Heals + Detox Better than All Others by Dr. Josh Axe

2. Healthy & Healing's Detoxification: Programs to Cleanse, Purify & Renew by Linda Page, Ph.D. [

3. A Study on Wheat Grass & It's Nutritional Value by Dr. Ramesh Babu Bodla [

4. Chlorophyll as Therapy - Cancer - Germs - Intestines by H.E. Kirschner, M.D.

5. The Detox Revolution

6. Body Detox: A Guide to Health and Rejuvenation

7. 6 Ways to Detox With Chlorophyll by Just Cleansing

8. The Benefits of Chlorophyll

9. Mechanisms of Chlorophyllin Anticarcinogenesis Against Aflatoxin B: Complex Formation with the

10.  Carcinogen

11. Oxidative Stress Response in Canine In Vitro Liver, Kidney and Intestinal Models With Seven

12. Potential Dietary Ingredients

13. Effects of Chlorophyll and Chlorophyllin on Low Dose Aflatoxin B(1) Pharmacokinetics in Human

14. Voluneers

15. Study of the Forces of Stabilizing Complex between Chlorophylls and Heterocylic Amine Mutagens

16. Chlorophyllin Reduces Aflatoxin Indicators Among People at High Risk for Liver Cancer

17. Natural Compounds in the Human Diet and Their Ability To Bind Mutagens Prevents DNA-Mutagen

18. Intercalation

19. E2F4 and Ribonucleotide Reductase Mediate S-Phase Arrest in Colon Cancer Cells Treated With Chlorophyllin

20. What is Detox Chlorophyll Water & Why is Everyone Sipping It?

21. Chlorophyllin Protects Against Environmental Toxins

22. A Study of Chlorophyllin of Medicinal Plants, It's Chemical Characterization

23. Relative Delivery Efficiency and Convenience of Spray and Ointment Formulations of Papain/Urea/Chlorophyllin

24. Enzymatic Wound Therapies

25. Low-Dose Dietary Chlorophyll Inhibits Multi-Organ Carcinogenesis in Rainbow Trout

26. Chlorophyllin e4 is a Novel Photosensitizer Against Human Bladder Cancer Cells

27. Chlorophyllin Significantly Reduces Benzo[a]pyrene BP-DNA adduct Formation and Alters Cytochrome

28. P450 1A1 and 1B1 Expression and EROD Activity in Normal Human Mammary Epithelial Cells

29. Chempreventative Properties of Chlorophyllin: Inhibition of Aflatoxin B1 (AFB1)- DNA Binding in Vivo and Anti Mutagenic activity against AFB1 and two heterocyclic amines in the Salmonella Mutagenic Assay

30. Gene Expression Signature of DMBA-Induced Hamster Buccal Pouch: Modulation by Chlorophyllin and Ellagic Acid

31. Colour Addavites for Foods and Beverages

32. Handbook of Natural Colorants

33. Chlorophyllin For The Control of Ichthyophthirius Multifilis

34. Chemoprevention with Chlorophyllin in Individuals Exposed to Dietary Afllatoxin

35. Dietary Aflatoxin Exposure and Chemoprevention of Cancer, a Clinical Review

09. Boosts Your Immune System

“A healthy immune system is the foundation to maintaining good health. It protects us from disease and keeps germs, bacteria, and viruses at bay.Chlorophyll can have a powerful effect in enhancing the immune system. It stimulates the bone marrow, which is responsible for the production of white blood cells. The job of these cells is to protect our body from infectious disease and ward off any foreign invaders that could potentially make us sick.When levels of white blood cells drop, it can cause a weakened immune system, opening the door for viral infections and diseases to take hold.” – Source: Yuriel Kaim

“Chlorophyllin (CHL) was earlier shown to reduce the level of intracellular ROS and apoptosis induced by ionizing radiation and 2,2'-azobis(2-propionimidinedihydrochloride) (AAPH). In the present studies, the effect of CHL on radiation-induced immunosuppression and modulation of immune responses in mice was examined. Chlorophyllin inhibited the in vitro lymphocyte proliferation induced by concanavalin A (Con A) in a dose dependent manner at doses>or=50 microM.” – Source: Molecular Immunity Journal

“All of the compounds examined, including chlorophyll a, required the presence of pi-pi interactions to form stable complexes with the heterocyclic amines. In general, the present results were in agreement with the inhibitory potency of each compound in the Salmonella assay, and they provide further support for the hypothesis that chlorophylls in the diet might act as interceptor molecules of food-borne carcinogens and mutagens.” – Source: Environmental Mutagen Journal

“One of the most potent inducers was isolated from chlorophyllin, a semisynthetic water-soluble chlorophyll derivative. Although chlorophyll itself is low in inducer potency, it may nevertheless account for some of the disease-protective effects attributed to diets rich in green vegetables because it occurs in much higher concentrations in those plants than the widely studied 'phytochemicals'. – Source: Carcinogenesis Journal

“Chlorophyllin was evaluated in the mouse bone marrow micronucleus test for its possible protective effects against chromosomal damage induced by gamma-radiation, cyclophosphamide, N-nitroso-N-ethylurea and urethane. Three doses of chlorophyllin (50, 100 and 200 mg/kg, b.w.) were orally administered to mice 2 h before exposure to the clastogens under investigation. The results obtained demonstrated that chlorophyllin can significantly reduce the incidence of micronucleated polychromatic erythrocytes induced by gamma-radiation (1.15 Gy) and all the three chemical clastogen.” – Source: Genetic Toxicology Journal

 “Chlorophyll enhances your immune system, which is always great because your immune system is what keeps you healthy. This pigment stimulates the bone marrow, which is the grounds for production of white blood cells, and WBCs ward off bacterial and viral invaders, thus fighting off infection.” – Source: Spoon University  

 “Chlorophyllin is known to inhibit the mutagenicity of a variety of compounds. Using highly purified samples of chlorophyllin and its family compounds, we studied the mechanism of the inhibition. Since mutagens with polycyclic planar structures are particularly strongly inhibited, it seemed likely that the inhibition arises by trapping of the mutagens by chlorophyllin through complex formation at the planar surfaces of these molecules.” – Source: Fundamental and Molecular Mechanisms of Mutagensis Journal  

 “Chlorophyllin (CHL), a sodium/copper derivative of chlorophyll, has been used to treat a number of human conditions with no toxic effects being reported. Recent studies have described the anti-mutagenic activity of CHL in several short-term genotoxicity assays; however, this compound has not been reported to inhibit carcinogen--DNA binding in vivo, and it has yet to be evaluated as an anti-carcinogen in any species. The chemopreventive properties of CHL were studied in trout using inhibition of aflatoxin B1 (AFB1)--DNA binding as an end-point.” – Source: Carcinogensis

 “During the 1950s, many laboratories tested chlorophyll's power to kill germs. The consensus of these reports was that, for the most part, chlorophyll is bacteriostatic, and only slightly bacteriocidal. This means that chlorophyll limits the growth of many types of germs not by directly killing them, but by providing an environment which interferes with their growth. It is particularly effective against anaerobic bacteria, those which do not require oxygen. Dentists and physicians have successfully used chlorophyll to control mouth infections such as pyorrhea and Vincent's angina. Chlorophyll solutions provide significant relief of pain, reduction of inflammation, and the control of odor for patients with serious mouth diseases. There are several reported cases of the successful use of chlorophyll for bacterial endocarditic, an infection of the tissue surrounding the heart. Chlorophyll has also been used successfully to treat chronic and acute sinusitis, vaginal infections, and chronic rectal lesions.” – Source: H.E. Kirschner, M.D.  

 “Copper chlorophyllin (total 180 mg per day for 3 weeks) was also effective at reducing free urinary TMA concentration and increasing TMAO to those of concentrations present in normal individuals. In the TMAU subjects examined, the effects of copper chlorophyllin appeared to last longer (i.e., several weeks) than those observed for activated charcoal. The results suggest that the daily intake of charcoal and/or copper chlorophyllin may be of significant use in improving the quality of life of individuals suffering from TMAU.” – Source: Life Sciences Journal

A study found that introducing Chlorophyll supplements into the diet induces weight loss, improves obesity-related risk factors, and reduces the urge for palatable food. Subjects in an extensive Oregon State University research study taking Chlorophyll lost significantly more weight than the group who took a placebo. Other research has shown that chlorophyll increases the likelihood of weight-loss success and has positive effects on the metabolism. Chlorophyll supplements helped to balance the release of the hormones that make us feel fuller, and research suggests that it might help naturally suppress the urge for food intake and prevent weight-gain.

More resources

1. Chlorophyllin Intervention Reduces Aflatoxin-DNA Adducts in Individuals at High Risk of Liver Cancer

2. Dietary Chlorophyllin Is A Potent Inhibitor of Aflatoxin B1Hepatocarcinogensisis in Rainbow Trout

3. Conjugation of cRGD Peptide in Chlorophyll-a Based Photosensitizer Alters it's Pharmacokinetics

4. Chlorophyll, Chlorophyllin and Related Tetrapyrroles Are Significant Inducers of 2

5. Cytoprotective Genes

6. Chlorophyll: Structural Properties, Health Benefits and it's Occurrence in Virgin Olive Oils Academic Food

7. Chlorophyllin as a Possible Measure Against Vectors of Human Parasites and Fish Parasites

8. Role of Chlorophyllin As An In Vivo Anticlastogen: Protection Against Gamma-Radiation and Chemical Clastogens

9. Detoxification: All You Need to Know to Recharge , Renew and Rejuvenate Your Mind, Body & Spirit

10. Wonders of Chlorophyll, the Green Plant Pigment

11. E2F4 and Ribonucleotide Reductase Mediate S-Phase Arrest in Colon Cancer Cells Treated with Chlorophyllin

12. Binding of Polycyclic Planar Mutagens to Chlorophyllin Resulting in Inhibition of Mutagenic Activity

13. 9 Little-Known Benefits of Taking Liquid Chlorophyll by Nutritionist Yuri Elkaim

14. Anthelminitic Activity of Chlorophyllin Against Different Larval Stages of Fasciola Gigantica

15. Identification and Characterization of Chloro e(4) ethyl ester in Sera Individuals Participating in the Chlorophyllin Chemoprevention Trial

16. Analysis of the Therapeutic Effect of Sodium Copper Chlorophyllin Tablet in Treating 60 Cases of Leukopenia

17. Antimutagenic Activities of Common Vegetables and Their Chlorophyll Content

18. Digestion, Absorption, and Cancer Preventative Activity of Dietary, Chlorophyll Derivatives

19. Inhibitory Effect of Hemin, Chlorophyllin and Related Pyrrole Pigments on Mutagenicity of Benzo[a]pyrene and It’s Metabolites

20. The Importance of Chlorophyll in Our Diets by Liz Barrington

21. A Short Review of the Medicincal Properties of Chlorophyll Juice

22. Antipoptotic and Immunomodulatory Effects of Chlorophyllin

23. Anticlastogenicity of Chlorophyllin in the Different Cell Cycle Phases In Cultured Mammalian Cells

24. Chemoprevention with Chlorophyllin In Individuals Exposed to Dietary Aflatoxin

25. Study of the Forces of Stabilizing Complex between Chlorophylls and Heterocylic Amine Mutagens

10. Anti-Inflammatory & Fight Oxidative Stress

“Chlorophyll is a powerful antioxidant with both anti-inflammatory and anti-bacterial properties providing excellent health benefits both internally and when used in topical applications," says Nicholas Perricone, M.D., a dermatologist and creator of skincare brand Perricone MD.” – Source: InStyle

“Chlorophyll is great for helping the body detox and can help clear such things as heavy metals in your body. It is also important for supporting a healthy immune system and helps control inflammation. Liquid chlorophyll is particularly beneficial since it's better at getting absorbed faster in the body.” – Source: Dr. Renee Wellenstein

“Functional beverages are rich in vitamins and antioxidants. A 2016 review featured in the Journal of Food Science and Technology analyzed several grass beverages for their chlorophyll and antioxidant content. Barley grass juice appears to be higher in chlorophyll and gallic acid than wheat and rice grass drinks. Researchers also pointed out that chlorophyll has a similar structure to hemoglobin and may help protect against cancer. Another study, which was published in Food and Nutrition Sciences in 2013, highlights the antioxidant power of this plant compound. Scientists suggest that chlorophyll may prevent DNA damage and lipid peroxidation, reduce cancer risk and improve overall health. These potential benefits are thanks to its ability to scavenge free radicals. Smoking, pollution, processed foods and household chemicals all accelerate the production of free radicals in the body, according to Medical News Today. These harmful compounds have been linked to a higher risk of cancer, inflammatory disorders, neurodegenerative diseases and premature aging. They also affect your eyesight and promote the onset of cataracts. Drinking liquid chlorophyll and other functional beverages may help reduce oxidative stress and offset free radical damage.” – Source: Livestrong

“Consuming chlorophyll may help slow down aging and rejuvenate your cells, according to a study published in Peer-Reviewed & Open Access. Researchers found that feeding chlorophyll to nematodes from the Caenorhabditis elegans species helped increase their lifespan by increasing resistance to oxidative stress.16  - Source: ProHealth

“The results revealed that the Zn-pheophytins showed the highest 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging and β-carotene bleaching activities, followed by chlorophylls and pheophytins. Additionally, Zn-pheophytins showed substantial inhibitory activity against lipopolysaccharide (LPS)-induced NO production in RAW 264.7 cells. Furthermore, Zn-pheophytins remarkably suppressed LPS-induced expression of inducible nitric oxide synthase (iNOS) in RAW 264.7 cells and showed no cytotoxicity. Our findings indicated that Zn-pheophytins have strong antioxidant and anti-inflammatory properties and can therefore be a potential source of bioactive compounds for nutraceutical, cosmetic, and pharmaceutical applications.” – Source: Food Chemistry Journal

“The antioxidant effects are among the most firmly established activities exerted by chlorophylls. For instance, it has been documented that chlorophyllin confers a higher degree of protection against free radicals in comparison to other antioxidants such as ascorbic acid and glutathione [38]. In fact, we recently observed that the antioxidant effects of the tetrapyrroles, bilirubin, and phycocyanobilin dramatically differed from those of other antioxidants. The most prominent feature of their action was the attenuation of mitochondrial ROS production [39, 40]. Here, we have shown that the same is true for chlorophylls. All chlorophylls tested not only consistently improved total peroxyl radical-scavenging activities but also suppressed the production of mitochondrial ROS and total cellular hydrogen peroxide by cancer cells, accompanied by a shift of the glutathione redox status towards a reduction.” – Source: Oxidative Medicine and Cellular Longevity Journal

“In a study published in 2000, researchers looked at the protective effects of chlorophyllin on various organs and mitochondrial membranes in mice and rats.34 The authors of this study showed that not only did chlorophyllin protect mice brains, liver, and testes from oxidative damage, but it also proved to be a potent free radical scavenger in rat liver mitochondria, leading the researchers to conclude “ ...our studies showed that CHL [chlorophyllin] is a highly effective antioxidant, capable of protecting mitochondria against oxidative damage...In another study using rat liver mitochondria, researchers showed that chlorophyllin provided significant protection against ionizing radiation, a potent generator of free radicals.35 Finally, with mitochondrial damage strongly implicated in the aging process,36-38 chlorophyllin may very well be useful in preventing chronic diseases and premature senescence.” – Source: Life Extension Magazine

“Increasing chlorophyll contents corresponded to increasing antimutagenic activities in all 3 groups. Sodium copper chlorophyllin demonstrated comparable inhibitory activity when compared at the same chlorophyll level.” – Source: Genetic Toxicology Journal

“Sodium copper chlorophyllin (CHL) is a semi-synthetic mixture of water-soluble sodium copper salts derived from chlorophyll, widely used as food dye (Chernomorsky, Rancourt, Virdi, Segelman, & Poretz, 1997;Tumolo & Lanfer-Marquez, 2012). Its anti-mutagenic and anti-carcinogenic activities against numerous dietary and environmental agents, including the mycotoxin aflatoxin B 1 , heterocyclic amines, and polycyclic aromatic hydrocarbons have been recorded (reviewed in Tumolo & LanferMarquez, 2012).” – Source: Food Research International Journal

“Chlorophyllin, the sodium and copper salt of chlorophyll, was tested for its ability to inhibit the mutagenic activity of a variety of complex mixtures — extracts of fried beef, fried shredded pork, red grape juice, red wine, cigarette smoke, tobacco snuff, chewing tobacco, airborne particles, coal dust and diesel emission particles — in strain TA98 of Salmonella typhimurium. Chlorophyllin was highly effective against the mutagenicity (90–100% inhibition) of 8 of these 10 mixtures.” – Source: Mutation Research Letters

“The study shows that chlorophyll a and its degradation products are valuable and abundantly available anti-inflammatory agents and promising for the development of phytomedicine or conventional medicine to treat inflammation and related diseases.” – Source: Chlorophyll Revisited: Journal

“Chlorophyllin, the water-soluble analogue of the ubiquitous green pigment chlorophyll has been shown to be a potent antioxidant and radioprotector under both in vitro and in vivo conditions. It is a potent protector of membrane damage and prevents protein oxidation, lipid peroxidation besides depletion of thiols induced by radiation, photosensitization and other oxidants.” – Source: Bhabha Atomic Research Centre

“The antioxidant activity of six natural isolated chlorophyll derivatives and Cu-chlorophyllin was investigated by measuring their protective action against lipid oxidation. For this, the β-carotene bleaching method and the stable radical 2,2-diphenyl-1-picryldrazyl (DPPH) scavenging assay were employed. The results obtained by the β-carotene bleaching method showed that all chlorophyll derivatives presented a dose-dependent response.” – Source: Food Research International

“Chlorophyllin has bacteriostatic properties aiding in wound healing, and stimulates the production of hemoglobin and erythrocytes in anemic animals. It has been used to treat various kinds of skin lesions, burns and ulcers where it acts as a wound healing agent, stimulating granulation tissue and epithelization [48].” – Source: International Journal of Chemical Studies  

“Chlorophyll has  potent anti-inflammatory properties and has been used against a host of inflammatory conditions like arthritis, sinusitis, pancreatitis, and respiratory conditions. It also is an antioxidant, scavenging free radicals to reduce oxidative stress on the body. Chlorophyll is also considered one of nature’s most potent chelating agents, which means it binds to heavy metals in the body, helping to render them useless so they can be eliminated (3). Another health benefit of chlorophyll is in its Vitamin K, which stimulates the adrenal system and helps in detoxifaction. It stimulates anti-aging hormones, thus helps the body to rejuvenate and rebuild itself.” – Source: Yuri Elkaim

“Chlorophyll is also an effective deodorizer to reduce bad breath, urine, fecal waste, and body odor. It may reduce the ability of carcinogens to bind with the DNA in different major organs in the body. Chlorophyll may be useful in treating calcium oxalate stone ailments. It possesses some anti-atherogenic activity as well. It can be used to treat infected wounds naturally. It has antimutagenic and anticarcinogenic properties so that it may be helpful in protecting your body against toxins and in reducing drug side effects.” – Source: Journal of Pharmacy Research

“Chlorophyllin (CHL) has been examined as an antioxidant/radioprotector in splenic lymphocytes from BALB/c mice. CHL inhibited lipid peroxidation induced by 2,2′-azobis(2-propionimidinedihydrochloride) (AAPH) in lymphocytes in vitro. It also partially prevented radiation-induced suppression of mitogenic stimulation of lymphocytes in vitro.” – Source: Biochimica et Biophysoca Acta  

more resources

1. Picosecond Dynamic of Aqueous Sodium-Copper Chlorophyllin Solution: An Excited State Absorption Study

2. Antioxidants in Photosynthesis and Human Nutrition

3. Chlorophyllin as a Protector of Mitochondrial Membranes Against Gamma-Radiation and Photosensitization

4. Chlorophyllin As An Effective Antioxidant Against Membrane Damage In Vitro and Ex Vitro  

5. Chlorophyll-Mediated Changes in the Redox Status of Pancreatic Cancer Cells Are Associated w/ It's Anticancer Katerina Vankova, Ivana Markova, Jana Jasprova, Ales Dvorak

6. Chlorophyllin As An Effective Antioxidant Against Membrane Damage In Vitro and Ex Vitro  

7. Copper Chlorophyll: A Food Colorant with Bioactive Properties

8. Chlorophyllin: A Potent Antimutagen Against Environmental and Dietary Complex Mixtures

9. Scavenging of Reactive Oxygen Species by Chlorophyllin: An ESR Study

10. Mechanisms Responsible For The Antioxidant Properties of Chlorophyllin

11. The Antioxidative and Antipoptotic of Chlorophyllin on a Female Rat Spleen Exposed to Localized Gastric

12. Radiotherapy

13. Food Antioxidants Are Superior to Isolated Antioxidants

14. Chlorophyll In Tomato Seeds: Marker for Seed Performance?

15. Chlorophyll Revisited: Anti-Inflammatory Activities of Chlorophyll

16. Sodium Copper Chlorophyllin: In Vitro Digestive Stability and Accumulation by Caco-2 Human

17. Intestinal Cells [Journal of Agriculture and Food Chemistry]

18. Antioxidant Activity of Chlorophylls and Their Derivatives [Food Research International]

19. Chlorophyll In Your Diet [Livestrong]

20. Effect of Chlorophyllin Against Oxidative Stress in Splenic Lymphocytes in Vitro and In Vivo[Biochimica et Biophysica Acta]

21. Living Life The Natural Way – Wheatgrass and Health [Post Graduate Institute of Medical Education and Research]

22. Comparisons of Curative Effects of Chlorophyll from Sauropus Androgynus Merr Leaf Extract [Journal of Toxicology]

    
    

11. Ward Off Chronic Diseases

“Chlorophyllin (Chln), a sodium-copper salt derivative of chlorophyll, like chlorophyll-a and -b found in green plants, has been studied for its protective action against the carcinogenic effects of various physical and chemical agents and in relation to the mutagenic and clastogenic activities of genotoxic agents.” – Source: Mutation Research Journal  

“Increasing chlorophyll contents corresponded to increasing antimutagenic activities in all 3 groups. Sodium copper chlorophyllin demonstrated comparable inhibitory activity when compared at the same chlorophyll level.” – Source: Genetic Toxicology Journal

“This study compared the binding properties of natural compounds in the human diet (caffeine, theophylline, theobromine, and resveratrol) with a water-soluble derivative of chlorophyll to bind to acridine orange, a known mutagen. An analysis was conducted to determine which substances were effective binding agents and may thus be useful in prevention of chemical-induced mutagenesis and carcinogenesis.” – Source: Toxicology Environmental Health Journal

“The growing body of epidemiological and experimental evidence associating diets rich in fruits and vegetables with prevention of chronic diseases such as cancer has stimulated interest in plant food phytochemicals as physiologically active dietary components. Chlorophyll and its various derivatives are believed to be among the family of phytochemical compounds that are potentially responsible for such associations.” – Source: Nutrition Research Journal 

“Chlorophyllin was evaluated in the mouse bone marrow micronucleus test for its possible protective effects against chromosomal damage induced by gamma-radiation, cyclophosphamide, N-nitroso-N-ethylurea and urethane. Three doses of chlorophyllin (50, 100 and 200 mg/kg, b.w.) were orally administered to mice 2 h before exposure to the clastogens under investigation. The results obtained demonstrated that chlorophyllin can significantly reduce the incidence of micronucleated polychromatic erythrocytes induced by gamma-radiation (1.15 Gy) and all the three chemical clastogen.” – Source: Genetic Toxicology Journal

“Chlorophyll and its derivatives are very effective at binding polycyclic aromatic hydrocarbons (carcinogens largely from incomplete combustion of fuels), heterocyclic amines (generated when grilling foods), aflatoxin (a toxin from molds in foods which causes liver cancer), and other hydrophobic molecules. The chlorophyll-carcinogen complex is much harder for the body to absorb, so most of it is swept out with the feces. The chemoprotective effect of chlorophyll and its derivatives has been tested in laboratory cell cultures and animals [107, 108]. There is so much compelling evidence for anti-carcinogenic effects of chlorophyll that a prospective randomized controlled trial is being conducted in Qidong, China to see if chlorophyllin can reduce the amount of liver cancer cases, which arise from aflatoxin exposure in their foods (corn, peanuts, soy sauce, and fermented soy beans).” – Source: Nutritional Journal

“Wheatgrass juice is one of the most popular functional beverages on the market — and for good reason. Rich in chlorophyll, amino acids and micronutrients, it may help protect against chronic diseases and add years to your life. According to a 2014 pilot study published in the International Journal of Chemical Studies, this beverage can prevent anemia thanks to its high chlorophyll content. Patients with beta-thalassemia, a disorder that affects hemoglobin synthesis, required fewer blood transfusions and reported general well-being and pain relief after drinking wheatgrass juice every day.

Researchers have also found that chlorophyll accelerates tissue repair and wound healing. Furthermore, it may increase lifespan due to its anticancer, antioxidant and detoxifying properties. The same study outlines its ability to fight inflammation and inhibit bacteria growth. As WebMD notes, this plant compound is possibly effective for pancreatitis treatment. Chlorophyll injections may improve the symptoms associated with this condition.” – Source: Livestrong

“Chlorophyllin (CHL), the water-soluble analogue of chlorophyll, has been examined for its ability to inhibit membrane damage induced by y-radiation and photosensitization involving methylene blue plus visible light. Using rat liver mitochondria as model systems the mechanisms of damage induced by these two agents as well as its possible prevention by CHL have been examined.” – Source: Toxicology Journal  

“Chlorophyllin is a promising chemo preventive agent to block cancer primarily by inhibiting carcinogen such as AFB1. Methods: In the present study the bioactive pigment, chlorophyllin was extracted and estimated from six medicinal plant leaves and characterized by IR and NMR. Further, based on the high chlorophyllin content (12.21µg/ml), Solanum trilobatum L. was selected for the study of anticarcinogenic property against two types of cell lines: HepG2 cell lines (Human Hepatocellular Carcinoma) and Vero cell lines (African Green Monkey kidney).” – Source: International Journal of Pharmacy and Pharmaceutical Sciences  

“Chlorophyllin (CHL), a water-soluble derivative of chlorophyll, forms molecular complexes with heterocyclic amine mutagens in vitro. In a previous study [Dashwood and Guo (1993): Environ Mol Mutagen, 22:164-171], we observed an inverse correlation between the binding constants of several mutagen-CHL complexes and the antimutagenic potency of CHL in the Salmonella assay.” – Source: Environmental Mol Mutagen Journal

“Chlorophyll (Chla) and chlorophyllin (CHL) were shown previously to reduce carcinogen bioavailability, biomarker damage, and tumorigenicity in trout and rats. These findings were partially extended to humans, where CHL reduced excretion of aflatoxin B(1) (AFB(1))-DNA repair products in Chinese unavoidably exposed to dietary AFB(1).” – Source: Cancer Prevention Research Journal  

“Chlorophyllin (CHL), a water-soluble form of chlorophyll,  was recently evaluated as a chemopreventative agent  in a population at high risk for exposure to aflatoxin  and subsequent  development of hepatocellular carcinoma. CHL, which is used extensively as a  food colorant and has numerous medicinal applications, is an effective anticarcinogen in experimental models including aflatoxin-induced hepatocarcinogenesis. CHL is thought to form molecular complexes with carcinogens, thereby blocking their bioavailability.” – Source: Mutation Research Journal

“Analysis of the therapeutic effect of sodium copper chlorophyllin tablet in treating 60 cases of leukopenia.” – Source: China Journal of Integrated Medicineh”

“Chlorophyllin (CHL), a mixture of water soluble derivatives of chlorophyll, has been shown to be an effective inhibitor of aflatoxin B(1) (AFB(1)) carcinogenesis and AFB(1)-DNA adduct formation in rainbow trout and rats [Breinholt, V., Hendricks, J., Pereira, C., Arbogast, D., and Bailey, G. (1995) Cancer Res. 55, 57-62; Kensler, T. W., Groopman, J. D., and Roebuck, B. D. (1998) Mutat. Res. 402, 165-172]. The chemopreventive action of CHL has been previously attributed to molecular complexing. In 1997, a randomized, double-blind clinical trial of CHL was conducted in Qidong, Jiangsu Province, People's Republic of China” – Chemical Research Toxicology Journal

“Chlorophyllin and its formulations + FCU were 357.4 to 1603.5 times more effective against redia/cercaria larvae in sunlight than under laboratory conditions. The present study has shown that chlorophyllin formulations may be used as potent larvicides against fasciolosis.” – Source: Institute of Medicine Journal  

“According to the Journal of Food Science, dietary chlorophyll contains antioxidant and antimutagenic properties that may benefit your health by fighting free radicals throughout your body.15- Source: ProHealth

12. Skin Healing

 “Chlorophyllin has been shown to reduce inflammation and bacterial growth in skin wounds. A review of wound care studies found that commercial ointments with papain-urea-chlorophyllin are more effective than other treatments. The ointment also reduced pain and healing time by half. Your doctor can prescribe this ointment. Chlorophyllin may also be effective for mild to moderate acne. In a 2015 study, people with acne and large pores saw skin improvement when they used topical chlorophyllin gel for three weeks.” Source: Healthline

“Chlorophyll helps wounded cells repair themselves and behave like healthy cells, which means the cells are able to regenerate themselves. This is why stem cell therapy works. More on that another time. It has been suggested that stimulating healing can improve fine lines and wrinkles. This is because the—let’s say toxicity—causing your fine lines and wrinkles gets a rejuvenating boost of positive energy.” – Source: Poosh

“Will drinking chlorophyll help with acne? "The trials and research on this are still being done, but there is some evidence that supports orally taken chlorophyll in an anti-aging regimen," explains Nazarian. "Chlorophyll's natural antioxidants are thought to fight free radical damage, leading to improvement in signs of skin aging, such as decreased wrinkles and repairing DNA damage." – Source: Byrdie

“Her instincts are spot-on. “Chlorophyll can certainly help when thinking of ways to keep your skin looking younger and healthier in a more natural way,” Dr. Devika Icecreamwala, a board-certified dermatologist based in San Francisco, confirms to The Zoe Report. “It’s an excellent source of vitamins A,C, E, and K — these can act to replenish the skin and keep it firm, increase collagen production, and help reduce free radical damage.” – Source: The Zoe Report

“Ability of sodium copper chlorophyllin complex to repair photoaged skin by stimulation of biomarkers in human extracellular matrix.” – Source: Clinical, Cosmetic and Investigational Dermatology

“Chlorophyllin has bacteriostatic properties that aids in wound healing [45]. It has been used to treat various kinds of skin lesions, burns, and ulcers, where it acts as a wound-healing agent, stimulating granulation tissue and epithelialization [46]. It was reported that rate of Functional Foods in Health and Disease 2011, 1(11):444-456 Page 451 of 456 healing with chlorophyll is so rapid that its inclusion in armamentarium of burn treatment is suggested because it completely supersedes sulphonamide compounds as primary dressing for clean and potentially infected wounds [47].” – Source: Functional Foods and Health Disease

“The use of chlorophyll to promote the healing process was first reported nearly 100 years ago. One report published by Butler University (in 1950!) discussed its use for improving healing times. [3] A more recent study found that, when used as a spray, chlorophyll significantly helped wound therapy. [4] The research clearly backs its effectiveness in this area.” – Source: Global Healing Center

Chlorophyll is basically a green elixir that can naturally help treat various kinds of ailments and has shown some sort of benefits when it comes to preventing cancer. In addition to this, it can work wonders for your skin. If you’re wondering where to land it, you’ll find it at most chemists and even online! Now, who thought that the substance responsible for soaking up sun and transforming it into food for plants can help solve a number of skin problems? Well, this just proves that green is good” – Source: Be Beautiful

“To determine the relative delivery efficiency and user preference for spray and ointment formulations containing papain, urea, and chlorophyllin copper complex sodium (papain/urea/chlorophyllin copper complex). Participants applied both a spray and 3 ointment formulations of papain/urea/chlorophyllin copper complex to identical wound models.”  - Source: Journal of WOCN

“The liquid's also been shown to help enhance wound healing when applied topically so, by extension, it may have some pretty potent anti-aging benefits, as many topicals used to treat wrinkling have roots in skin healing. "By helping wounded cells repair themselves and behave like healthy cells, ingredients that stimulate healing might also improve fine lines and wrinkles," Zeichner said, before pointing out Chlorophyl has potent antioxidant effects, neutralizing free radicals, which are responsible for disrupting collagen production and DNA, which causes wrinkling and promotes skin cancer.” – Source: Glamour

"The trials and research on this are still being done, but there is some evidence that supports orally taken chlorophyll in an anti-aging regimen," explains Nazarian. "Chlorophyll's natural antioxidants are thought to fight free radical damage, leading to improvement in signs of skin aging, such as decreased wrinkles and repairing DNA damage." – Source: Byrdie

“So, if you ingest chlorophyll, you’ll be able to see the results on your face! Chlorophyll has a “detox” effect on the blood and also increases red blood cell production.This helps deliver oxygen to your skin cells. The oxygen will help your skin look and feel smoother and appear more radiant. Those who have tried chlorophyll have claimed to see a difference in their skin in a matter of days because of this. Chlorophyll is also high in vitamins A, C, E, and K and antioxidants, which protect against free radical damage. Over time, this damage can lead to the formation of fine lines and wrinkles, and even harm DNA.” – Source: Skin Care by Alana

“Research in the 1940s indicating that chlorophyllin slowed the growth of certain anaerobic bacteria in the test tube and accelerated the healing of experimental wounds in animals led to the use of topical chlorophyllin solutions and ointments in the treatment of persistent open wounds in humans (29). During the late 1940s and 1950s, a series of largely uncontrolled studies in patients with slow-healing wounds, such as vascular ulcers and pressure (decubitus) ulcers, reported that the application of topical chlorophyllin promoted healing more effectively than other commonly used treatments (30, 31). In the late 1950s, chlorophyllin was added to papain and urea-containing ointments used for the chemical debridement of wounds in order to reduce local inflammation, promote healing, and control odor (23). Chlorophyllin-containing papain/urea ointments are still available in the US by prescription (32). Several studies have reported that such ointments are effective in wound healing (33). Recently, a spray formulation of the papain/urea/chlorophyllin therapy has become available (34).” – Source: Oregon State University

“Due to chlorophyll’s incredible nutritional value, sipping on liquid chlorophyll daily will lead to an advantageous effect in your overall skin health as this “super food” is packed with a range of mighty nutrients such as: Vitamin A, Vitamin C, Vitamin E, Vitamin K, Beta Carotene, Magnesium, Iron, Potassium, Calcium, antioxidants, and essential fatty acids, in addition to being alkaline.” – Source: YogiApproved

“Chlorophyll for skin helps fade blemishes due to its antibacterial properties. As an antioxidant, it also removes toxins and cleanses the blood. Chlorophyll neutralizes pimples, fades redness, and reduces discoloration caused by other skin issues.” – Source: BioClarity

““There’s good reason for it to be appearing everywhere in beauty: It has so many benefits,” says natural beauty blogger Sonia Keu of the ingredient’s rise in popularity as a complexion booster. “Chlorophyll promotes your blood cell production, which means it gets oxygen delivered to your cells quickly. That balances your skin.” – Source: Well and Good

“Chlorophyll can certainly help when thinking of ways to keep your skin looking younger and healthier in a more natural way,” Dr.Devika Icecreamwala, a board-certified dermatologist, based in San Francisco, confirms to The Zoe Report. “It’s an excellent source of vitamins A,C, E, and K — these can act to replenish the skin and keep it firm, increase collagen production, and help reduce free radical damage.” 

 “Chlorophyll heals wounds. The ideal wound treatment stimulates repair of damaged tissues and inhibits the growth of bacteria. Chlorophyll does both! Even crude preparations of chlorophyll are effective in stimulating the growth of healthy granuloma tissue and fibroblasts—both on actual wounds and in laboratory cultures.” – Source: H.E. Kirschner, M.D

13. Anti-Aging

“Chlorophyll helps in combating the effects of aging and supports in maintaining healthy tissues attributing to the richness of antioxidants and the presence of magnesium. [15] It stimulates the anti-aging enzymes and encourages healthy and youthful skin. In addition to this, vitamin Kpresent in it cleans and rejuvenates the adrenal glands and improves the adrenal functions in the body. [16]” – Source: Organic Facts

“Interestingly enough, chlorophyll’s structure is similar to the hemoglobin in human blood that carries oxygen to each and every cell. It’s also been found to stimulate the tissue growth that can play a role in anti-aging. “In helping retain healthy skin tissues, chlorophyll stimulates anti-aging enzymes and encourages nourished, youthful skin,” shares Dr. Frieling.

It can also help repair sun damage on your skin in addition to fighting free radicals. “Studies suggest that chlorophyll is beneficial for photodamaged human skin, especially when individuals drink it,” says Dr. Hu. “Some research has indicated that drinking chlorophyll significantly improves wrinkles and elasticity.” In fact, a study of females age 45 and older who received a chlorophyll extract supplement for 90 days experienced a significant increase in collagen production, as well as a reduction in cellular lesions called thymine dimers that indicate UV damage. You can easily add drinkable chlorophyll to your life by snagging a bottle of Chlorophyll Water® ($40 for a case of 12 bottles). In lieu of juicing or making smoothies (or paying extra for someone else to do so!), this enhanced water will deliver your daily anti-aging dose of chlorophyll with every sip.” – Source: The Spotlyte

“Efficacy and Tolerability of an Acne Treatment Regimen with Antiaging Benefits in Adult Women.” – Source: The Journal of Clinical and Aesthetic Dermatology

“Topical chlorophyll may work as an anti-aging remedy. A study found that applying a gel containing chlorophyllin to the skin reduced signs of photoaging, which is aging that results from sun exposure. The study used skin samples from four healthy women and lasted for 12 days. The results of the study showed that skin treated with chlorophyllin improved in a similar way to skin treated with tretinoin, which is a prescription skin cream that has been proven to help with skin aging. The authors suggest that using a combination of chlorophyllin and tretinoin could be an effective treatment for reversing the signs of photoaged skin.” – Source: Medical News Today

“Clinical evidence supporting a role in preventing cutaneous aging is available for oral supplements such as carotenoids, polyphenols, chlorophyll, aloe vera, vitamins C and E, red ginseng, squalene, and omega-3 fatty acids. Collagen peptides and proteoglycans are claimed to provide building blocks of the dermal matrix. This review summarizes the current study findings of these functional foods.” – Source: Journal of  Lifestyle Medicine

“The free radical scavenging activity of chlorophyll makes it a vital ingredient in anti ageing bodies. Chlorophyll will also helps in retaining healthy tissues . It stimulates the anti aging enzymes and encourages healthy and youthful skin.” – Source: Asian Journal of Pharmaceutical Technology & Innovation

“Welcome to the antidote to your dietary sins. If you drink coffee, chloryphyll helps to negate its acidity. If you drink alcohol, it helps metabolize alcohol faster. If you eat non-organic produce or fish high in mercury, it helps remove these toxins. If you don't do any of these things (Good for you!), it simply enhances your own vitality. Chlorophyll is the green pigment in all green plants, but can be bought in a concentrated liquid form made from nettles or mulberry leaves.” – Source: Elle Magazine

“Taking chlorophyll extract supplements may also take years off your appearance. The 2014 study in the Journal of Lifestyle Medicine notes that study subjects who took chlorophyll extract supplements for 90 days showed improvements in facial wrinkles and skin elasticity. Authors of the review report that chlorophyll’s antioxidant properties likely play a role in wrinkle reduction.” – Source: FitDay

14. Weight Loss

According to Heathline, “One of the most popular claims associated with liquid chlorophyll is weight loss support. A study foundTrusted Source that people who took a green plant membrane supplement including chlorophyll on a daily basis had greater weight loss than a group that didn’t take the supplement. The researchers also found that the supplement reduced harmful cholesterol levels.” – Source: Healthline

According to Global Healing Center, “A study released in September of 2013 determined that compounds containing chlorophyll might help suppress hunger. Twenty moderately overweight women were given test meals on three separate occasions one week apart – two meals with chlorophyll, one without. They reported reduced hunger following the meals containing the chlorophyll and blood tests showed stable blood sugar levels. [1] These results suggest chlorophyll should be considered as an effective way to manage hunger and promote weight loss.” – Source: Global Healing Center

 “Chlorophyll exhibits strong antioxidant effects and may protect against free radical damage. A small number of studies suggest that it may also aid in weight loss by improving appetite control and reducing cravings.” – Source: Livestrong

 “Chlorophyll has been shown to have effect on appetite and is able to aid in weight loss. It works with our hunger hormones, which influence our appetite and regulate our intake. It’s been shown in several animal studies to help reduce food intake and prevent weight gain. A study in 2013 looked at how supplementing a high carbohydrate diet with chlorophyll affected how much food subjects ate. The researchers found that chlorophyll intensified feelings of satiety by reducing hunger and preventing the dip in blood sugar that often occurs 90 minutes after eating (1).” – Source: Yuriel Kim

“For example, one 2014 study looked at 38 overweight women who were following a weight-loss plan. The researchers found that over the course of 12 weeks, those who took a chlorophyll supplement once a day lost three additional pounds, on average, compared to those taking a placebo. The women in the chlorophyll group also experienced a greater decrease in LDL (or "bad") cholesterol, and a reduction in sweet cravings.” – Source: Health

“Chlorophyll is a plant-powered energy source that boasts a bunch of health perks. A study at Lund University in Sweden determined that people who took a green plant membrane supplement (like chlorophyll) on a daily basis lost more weight than a group that didn’t take the supplement. Beyond weight loss, a study published in the journal Clinical, Cosmetic and Investigational Dermatology found that applying a gel containing chlorophyllin (a derivative of chlorophyll) to the skin reduced signs of photoaging, otherwise known as aging that's caused by sun exposure.” – Source: PureWow 

“We have found that certain components from green leaves, the thylakoids, when given orally have a similar rationale in inducing the release of several gut hormones at the same time. In this way satiety is promoted and hunger suppressed, leading to loss of body weight and body fat. The mechanism is a reduced rate of intestinal lipid hydrolysis, allowing the lipolytic products to reach the distal intestine and release satiety hormones. The thylakoids also regulate glucose uptake in the intestine and influences microbiota composition in the intestine in a prebiotic direction. Using thylakoids is a novel strategy for treatment and prevention of obesity.” – Source: Plant Foods Human Nutritional Journal

 “Chlorophyll may help manage your weight and prevent overeating by helping control your hunger and food cravings. In one study, researchers fed 20 moderately overweight women meals that contained chlorophyll. Results indicate that the procedure was able to help suppress test subjects’ hunger by intensifying signals of satiety.18 - Source: ProHealth

15. Helps Fight Cancer

“Chlorophyll has shown potential as a cancer treatment. A 2015 review concluded that chlorophyllin might help prevent and slow cancer growth. A 2016 study found that chlorophyllin helped slow the progression of lung cancer.” Source: Medical News Today

“Chlorophylls have been shown to produce antiproliferative effects in pancreatic cancer cell lines (PaTu-8902, MiaPaCa-2, and BxPC-3) in a dose-dependent manner (10–125 μmol/L). Chlorophylls also have been observed to inhibit heme oxygenase (HMOX) mRNA expression and HMOX enzymatic activity, substantially affecting the redox environment of pancreatic cancer cells, including the production of mitochondrial/whole-cell reactive oxygen species, and alter the ratio of reduced-to-oxidized glutathione. Importantly, chlorophyll-mediated suppression of pancreatic cancer cell viability has been replicated in in vivoexperiments, where the administration of chlorophyll a resulted in the significant reduction of pancreatic tumor size in xenotransplanted nude mice. In conclusion, this data suggests that chlorophyll-mediated changes on the redox status of pancreatic cancer cells might be responsible for their antiproliferative and anticancer effects and thus contribute to the decreased incidence of cancer among individuals who consume green vegetables.” – Source: Oxidative Medicine and Cellular Longevity Journal

“Dietary chlorophyll is predominantly composed of lipophilic derivatives including chlorophyll a and b (fresh fruits and vegetables), metal-free pheophytins and pyropheophytins (thermally processed fruits and vegetables), as well as Zn-pheophytins and Zn-pyropheophytins (thermally processed green vegetables). Water-soluble derivatives including chlorophyllides, pheophorbides, as well as a commercial-grade derivative known as sodium copper chlorophyllin (SCC) also contribute to the diversity of dietary chlorophyll derivatives.” – Source: Nutrition Research Journal

“Chlorophyllin (Chln), a sodium-copper salt derivative of chlorophyll, like chlorophyll-a and -b found in green plants, has been studied for its protective action against the carcinogenic effects of various physical and chemical agents and in relation to the mutagenic and clastogenic activities of genotoxic agents.” – Source: Mutation Research Journal  

“Chlorophyllin (CHL) is a water-soluble derivative of chlorophyll that exhibits cancer chemopreventive properties, but which also has been studied for its possible cancer therapeutic effects. We report here that human colon cancer cells treated with CHL accumulate in S-phase of the cell cycle, and this is associated with reduced expression levels of p53, p21, and other G(1)/S checkpoint controls.” – Source: International Cancer Journal

“One of the most potent inducers was isolated from chlorophyllin, a semisynthetic water-soluble chlorophyll derivative. Although chlorophyll itself is low in inducer potency, it may nevertheless account for some of the disease-protective effects attributed to diets rich in green vegetables like wheatgrass because it occurs in much higher concentrations in these plants. [31].” – Source: International Journal of Chemical Studies  

 “Although many dietary compounds have been suggested to contribute to the prevention of cancer, there is a strong likelihood that wheatgrass extract, which contains chlorophyll, an antioxidant, may affect cancer prevention.” – Source: Functional Foods in Health and Disease

 “Although the use of chlorophyll derivatives, especially SCC, in traditional medical applications is well documented, it is perhaps the potential of chlorophyll as a cancer preventative agent that has drawn significant attention recently. Biological activities attributed to chlorophyll derivatives consistent with cancer prevention include antioxidant and antimutagenic activity, mutagen trapping, modulation of xenobiotic metabolism, and induction of apoptosis. Although most research has focused on commercial-grade SCC, the extent to which natural chlorophyll derivatives modulate biomarkers of cancer risk is also being explored. Recent research efforts have also included investigation of the impact of digestive factors on chlorophyll structure and bioaccessibility as a means to better understand the extent to which these pigments may be bioavailable in humans and therefore have more systemic impact in the prevention of cancer.” – Source: Nutrition Research Journal

 “More recent results of a clinical trial with chlorophyllin suggest that this drug may have a role in preventing dietary exposure to aflatoxin B1 by reducing its oral bioavailability. The preliminary results of these chemoprevention studies may ultimately have implications for cancer prevention in high-risk populations in the future.” – Source: Clinical Toxicology Journal

 “Chlorophyllin (CHL), a water-soluble, semi-synthetic derivative of chlorophyll and ellagic acid (EA), a naturally occurring polyphenolic compound in berries, grapes, and nuts have been reported to exert anticancer effects in various human cancer cell lines and in animal tumour models. The present study was undertaken to examine the mechanism underlying chemoprevention and changes in gene expression pattern induced by dietary supplementation of chlorophyllin and ellagic acid in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis model by whole genome profiling using pangenomic microarrays.” – Source: King Faisal Hospital & Research Center

 “Studies have found that chlorophyll and liquid chlorophyllin —a similar semi-synthetic mixture made in laboratories to be used in supplements, often called liquid chlorophyll — can bind to potential carcinogens and interfere with how they’re absorbed within the human gastrointestinal track. This helps stop them from being circulated throughout the body and reaching susceptible tissues, such as those within the joints or heart. Studies done by the Linus Pauling Institute at Oregon State University showed that chlorophyllin and chlorophyll were equally effective at blocking uptake of aflatoxin-B1 in humans and decreasing biomarkers of aflatoxin-induced DNA damage. (1) Findings from several other animal and human studies suggest that these effects help lower the risk for certain types of cancers, including liver and colon cancer.” Source: Dr. Axe.

“Researchers have looked into the effect of chlorophyll and chlorophyllin on cancer. One animal studyTrusted Source found that chlorophyll reduced the incidence of liver tumors by 29 to 64 percent and stomach tumors by 24 to 45 percent. There have only recently been human trials. A small study of four volunteers found that chlorophyll may limit ingested aflatoxin, a compound known to cause cancer. According to International Business Times, there’s currently a clinical trial in China on the effects of chlorophyllin on liver cancer. This trial is based on the findings from an old study where chlorophyllin consumption led to a 55 percent decrease in aflatoxin biomarkers.” -Source: Healthline

“Although the research doesn't currently show that chlorophyll is an all out cancer cure, researchers are excited about its potential as a therapy. One study found men with lower levels of dietary chlorophyll had higher risks of colon cancer. [9] Another study noted it effective at stimulating liver detoxifying enzymes and may protect against other carcinogens. [10] Source: Global Healing Center

 “Chlorophyll even reduces the likelihood of tumor development resulting from aflatoxin, providing powerful protection against the development of colon and liver cancer.[7] Further, a 2006 study conducted in the Netherlands found that men with a low consumption of the chlorophyll molecule in combination with high consumption of the heme molecule found in red meat experienced an increased risk of developing colon cancer.[9]” – Source: University Health News

 “Chlorophyllin (CHL), a water-soluble form of chlorophyll,  was recently evaluated as a chemopreventative agent  in a population at high risk for exposure to aflatoxin  and subsequent  development of hepatocellular carcinoma. CHL, which is used extensively as a  food colorant and has numerous medicinal applications, is an effective anticarcinogen in experimental models including aflatoxin-induced hepatocarcinogenesis. CHL is thought to form molecular complexes with carcinogens, thereby blocking their bioavailability.” – Source: Mutation Research Journal

 “Thus incorporating into our diets will aid in growth and repair of tissues and also possess anti mutagenic and anti carcinogenic properties to a certain extent as it is a very good chelating agent due to its physical and chemical structure. Thus we don’t have to rely on external chemicals or supplements for these benefits in keeping our body healthy and for increasing our immunity.” – Source: Journal of Pharmacy Research

 “Chlorophyll may help lower your risk of cancer by inducing apoptosis, according to a research published in Nutrition Research.11 In one documented study, the pigment has been found to help specifically with colon cancer.12 - Source: ProHealth

 “Chlorophyll protects against a whole host of carcinogens found in fungus-laden foods such as nuts and grains, the toxins from cooked meats, and air-borne carcinogens (from pollution). It blocks the metabolism in the body of harmful chemicals known as procarcinogens that damage DNA. Studies published in the journals Carcinogenesis and Food and Chemical Toxicology clearly display that chlorophyll inhibits carcinogenesis – and further research showing chlorophyll as being cancer-preventative.Researchers at Oregon State University also concluded: “At…cancer rates relevant to humans, chlorophyll was strongly protective”. – Source: Live Energized

 “Treatment with chlorophyllin e4 or laser light alone did not induce cytotoxicity. In addition, chlorophyllin e4-mediated PDT induced a significantly higher percentage of apoptosis in T24 and 5637 cells compared to the control groups (p<0.01). Moreover, confocal laser scanning microscopy revealed that chlorophyllin e4 co-localized with mitochondria in both cell lines. In conclusion, the remarkable photocytotoxicity, natural abundance and inexpensive composition of chlorophyllin e4 suggest that this compound may be a novel, effective photosensitizer for the treatment of human superficial bladder cancer.” – Source: Oncology Reports Journal

 “Reports on traditional medicinal uses of chlorophyll in alternative forms of medicine are known since ages. Now-a-days chlorophyll has been used in the field of medicine as remedy and diagnostics. Chlorophyll molecules are used in pharmacy as photosensitizer for cancer therapy. Their roles as modifier of genotoxic effects are becoming increasingly important, besides these it being known to have multiple medicinal uses. Chlorophyll has its place in modern medicine. Here, we present a review of recent developments in medicinal uses of chlorophyll. This article enumerates therapeutic claims of chlorophyll as drugs based on investigative findings of modern science. A brief overview of research and developments of medicinal uses of chlorophyll will be presented in this review along with challenges of potential applications of chlorophyll and its derivatives as chemotherapeutic agents.” – Source: Chlorophyll: Structure, Function and Medical Uses

 “Epidemiological and experimental evidence indicates a strong relationship between diet and cancer. The purpose of this study was to examine the potential of chlorophyllin (CHL), a food-grade derivative of the ubiquitous green plant pigment chlorophyll, to inhibit experimental carcinogenesis. We report that CHL is a potent, dose-responsive inhibitor of aflatoxin B1 DNA adduction and hepatocarcinogenesis in the rainbow trout model when fed with carcinogen.”  - Source: Cancer Research Journal

 “Chlorophyllin is a promising chemo preventive agent to block cancer primarily by inhibiting carcinogen such as AFB1. Methods: In the present study the bioactive pigment, chlorophyllin was extracted and estimated from six medicinal plant leaves and characterized by IR and NMR. Further, based on the high chlorophyllin content (12.21µg/ml), Solanum trilobatum L. was selected for the study of anticarcinogenic property against two types of cell lines: HepG2 cell lines (Human Hepatocellular Carcinoma) and Vero cell lines (African Green Monkey kidney).” – Source: International Journal of Pharmacy and Pharmaceutical Sciences  

 “Chlorophyllin (CHL) is a water-soluble derivative of chlorophyll that exhibits cancer chemopreventive properties, but which also has been studied for its possible cancer therapeutic effects. We report here that human colon cancer cells treated with CHL accumulate in S-phase of the cell cycle, and this is associated with reduced expression levels of p53, p21, and other G(1)/S checkpoint controls.” – Source: International Cancer Journal

 “Much attention in recent years has been given to the antigenotoxicity of chlorophyll. Chlorophyll, however, is known to be converted into pheophytin, pyropheophytin, and pheophorbide in processed vegetable food and following ingestion by humans. Studies were conducted on the antimutagenic and tumoricidal potencies of these compounds. All the chlorophyll derivatives tested exhibit identical antimutagenic effect towards 3‐methylcholanthrene (3‐MC), suggesting that the porphyrin nucleus may complex directly with the mutagen.” – Source: Carcinogensis and Mutagensis Journal

Best Food Sources of Chlorophyll

According to published reports, the best sources of chlorophyll are alfalfa, wheat grass, and aloe vera, many of which are easily blended into smoothies.

Green leafy vegetables and herbs that also contain chlorophyll and are  smoothie friendly are spinach, kale, coriander, parsley, celery, basil, and mint.

In the vegetable department, broccoli, cabbage, Brussels sprouts, and green tomato are rich in chlorophyll.

Another popular way to get chlorophyll into the diet is through taking supplements. These are available in the form of drops, pills, capsules, or through Chlorophyll Water.

CHLOROPHYLL INFORMATION AND DISCLAIMER

The Site contains information about Chlorophyll (“Chlorophyll Information”). Chlorophyll Information is collected by us from third party sources over which we have no control. We are not medical professionals or experts and do not and cannot attest to the accuracy of any of the information provided on this Site. None of the Chlorophyll Information on our Site has been evaluated or approved by the FDA.  Chlorophyll Information is not intended to be used for nutritional or medical diagnoses or treatment. The information provided on this website is intended for general interest only. The information provided is not intended to be a substitute for professional medical advice. You should not rely on this information as a substitute for, nor does it replace, professional medical advice, diagnosis, or treatment. If you have any concerns or questions about your health, you should always consult with a physician or other health-care professional. Do not disregard, avoid or delay obtaining medical or health related advice from your health-care professional because of something you may have read on this Site. The use of any information provided on this Site is solely at your own risk. The third parties who are quoted on our Site are not affiliated with our website. We have included quotes and other statements by these third parties based on our own interests. We have not consulted with such third parties, or requested their input or feedback. They have not endorsed our website, and we do not endorse them or their statements. We are not responsible for, and we do not warrant or represent that the third party statements are current, accurate, complete or reliable. The opinions expressed in these materials are strictly those of the speaker or author and do not necessarily reflect our views or opinions.

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